Study the effect of ethanolic extraction of Eucalyptus globulus against aflatoxin which causes liver damage in males rats

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Muthanna Journal of Pure Sciences – MJPS

VOL.4 – NO. 1 / January 2017

Laila Jasim Shaebth, and Samar Sahib Abbas

Technical Institute /Samawa/ Al-Furat Al-Awsat Technical University/ Samawa/ Iraq

Abstract

This study has been designed to evaluate the beneficial effects of Eucalyptus globulus extract upon Aflatoxin-causes hepatic toxicity, This study has been conducted on adult male rats at biology department in the college of the science\ University of AL-Qadisiya during the period extended from November, 2015 to February, 2016 (4 months). 40 mature male Wister rats, (age 90 days, weight 190±10 g) were separated in to four randomly equal groups Blood serum samples were separated for assessment of GOT, GPT, concentration. Under our experimental conditions, Aflatoxin poisoning resulted evidenced by statistically significant increase(p>0.05) in the activities of GOT, GPT in group 2 of just Aflatoxin compared with the control group, and in the third and fourth groups showed statistically significant decrease (p<0.05) in GOT, GPT level in Blood serum of Aflatoxin-treated group compared with the control group, After histological analysis of the group Aflatoxin proved change in the liver, after the gavage of (EUCE) The results showed that there is an improvement in liver tissues after treatment with EUCE .In present study we concluded to EUCE alcoholic dose 400mg/kg b.w. is better than dose 250mg/kg b.w. depending on results in recently study.
We concluded that the administration of (EUCE) act as antioxidant for Aflatoxin which induced toxicity of liver and antifungal against mycotoxins.
Keywords: Aflatoxin, Eucalyptus, Males rats, GOT, GPT.

 

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