The Control of warfarin drug post-prosthetic cardiac valve replacement

Muthanna Journal of Pure Sciences – MJPS

Vol.3 – No. 2 / October 2016

Salah A. Alkhadr
Muthanna University- College of Medicine


Depending on producing the scientific research on the clinical work in the hospitals, And the Academic work that based on guideline American collage of chest Physicians (ACCP) and the national heart the British society of hematology, And (ACC/AHA) 2015 for giving warfarin drug oral anticoagulation control prevention risk of bleeding and thromboembolism to keep on life’s people, After post implantation of prosthetic valve, Requires optimal consideration for anticoagulation, the current guideline recommends warfarin on all cardiac valve replacement, So most people in Iraq have taken a daily dosage from that (1mg–5mg) orally, Moreover take care this drug interaction with food and another drugs and it has another uses prevent ischemic stroke in atrial fibrillation (AF), Or venous thromboembolism (VTE), Deep vein thrombosis (DVT) after myocardial infarction (MI), This study included 52 patients’ in different ages and analysis, Concentration of the research is on the patients who make these operations cardiac replacement valve 36 cases randomized (men 19 and 17 women), So some people received warfarine under control without any risk, But the others have some complication So adding antiplatelet ( Aspirin or dipyridamole, Limited time aspirin) with warfarin reduced the thrombosis and total mortality (death), INR ( BT, PT, PTT) has a very important role in checking patients prophylactic in the safe International Normalsed ratio (INR) < 1.5 and in preparing operation Can be achieved by stopping anticoagulants 4 days before and starting again on the same day after the procedure. The after operations ratio of INR changes into 2-3 after giving warfarin to the patient from physician good ratio , Finally in the state of risk thromboembolism the INR Will be 2-3.5 maximum. After all these procedures the patient should take a drug to live a long time.


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