L-Arginine Effect on Serum glucose and lipid profile in diabetic Rats.

Muthanna Journal of Pure Sciences – MJPS
Volume 3 issue 1, 2016

Ahmed Sami Jarad*, Eyhab.R.M.AL-Samawy*, May Amer Al-Dahhan*
*AL-Muthanna University- College of Medicine
**AL-Muthanna University- College of Science


The present study was designed to investigate the effect of the amino acid
(LArginine-Hcl) on serum (glucose, lipid profile and lipid peroxidation) in alloxan
induced diabetes rats. Forty eight mature male rats aged 10weeks,were randomly
divided into four equal groups as follows 1st group diabetic group; 2nd group diabetic
group treated with (L-Arginine-Hcl), 3ed group treated with (L-Arginine-Hcl) and 4th
control group. After verifying the occurrence of diabetes in rats, the rats in second and
third groups were daily injectedwith L-Arginine-Hcl (200mg/kgB.W) intraperitonealy,
while first and fourth groups were daily injected with sterile distilled water
intraperitonealy. All experimental parameters were carried out at days 20, 40 and 60
were the blood samples were collected from heart to make serological parameters
(glucose level, lipid profile and MDA concentration) in different period. The diabetic
signs were clearly observed in first group characterized by excessive thirst, frequent
urination, and increase appetite, also first group showed significant increase (P<0.05)
in serum glucose, lipid (TC, TG, LDL-C and VLDL-C) and lipid peroxidation (MDA)
concentration. With significant decrease (P<0.05) in HDL-C concentration. In the
other hand the second group showed normal signs compared with first group with a
significantdecrease (P<0.05) in serum glucose level at day 40, significant decrease
(P<0.05) in serum TC and LDL-C at day 40. Also showed significant decrease
(P<0.05) in TG and VLDL-C concentration at day 60 and showed significant increase
in HDL-C at day 60 compared with first group, meanwhile the second group showed
significant decrease (P<0.05) in lipid peroxidation (MDA) at day 60. In conclusion the
L-Arginine has beneficial effect on normalization the hyperglycemia, regulate the
dyslipemia and decrease the level of lipid peroxidation.


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